Scott Nelson

Research Shows Red Light Therapy May Aid Memory Recovery and Prevent Cognitive Decline from Alzheimer’s and Dementia

Nearly 6 million Americans struggle with Alzheimer’s disease (AD), and worldwide, roughly 50 million people have some form of dementia. [1] Unfortunately, effective treatments have been slow to come. As one team of Alzheimer’s researchers wrote in a 2018 study on red light therapy and mice, “pharmacological treatments for Alzheimer’s disease have not resulted in desirable clinical efficacy for over 100 years.” [2] Another recent study noted there are “no current treatments to prevent the physical deterioration of the brain.” [3]

Peer-reviewed research on red light therapy as a potential treatment for Alzheimer’s & dementia-related brain degeneration and cognitive decline has been remarkably positive over the last few years in laboratory settings with rodent models. Based on this lab data, several teams of researchers have recommended red and near infrared light therapy for further use in human patients with AD.

We’ll look at the solid base of evidence from the laboratory over the past decade, but first here’s what the initial human studies on red light therapy and Alzheimer’s/dementia have shown in the past few years.

What is Red Light Therapy?

If you’re not familiar with red light therapy, this article gives a good overview of what it is and how it works. A Quality red light therapy device delivers safe, concentrated wavelengths of natural light to your skin and cells. This reduces oxidative stress and stimulates cellular energy production (adenosine triphosphate or ATP). To learn more about the science behind red light therapy, check out this article. This post breaks down the health benefits of red light therapy.

Joovv’s light therapy products are registered with FDA as class II medical devices for the treatment of pain, strain, and inflammation. Other health benefits mentioned in this article are for educational purposes only. See all applicable disclaimers at the end of this article.

Initial Human Studies Recommend Red Light Therapy for Alzheimer’s and Dementia Treatment

Two of the first double-blind, placebo-controlled human trials on dementia/AD and red light therapy were published in 2017, with extremely positive findings. The data showed red light therapy treatments produced positive changes in executive function, clock drawing, immediate recall, memory, visual attention, and task switching, as well as “a trend of improved EEG amplitude and connectivity measures.” [3,4]

One of these pilot studies reported that dementia patients treated with a 12-week transcranial light therapy routine experienced these “significant improvements”:

  • Increased cognitive function
  • Better sleep
  • Fewer angry outbursts
  • Less anxiety
  • Less wandering

Of major importance, this study also noted there were “no negative side effects.”

The study concluded that light therapy “shows potential for home treatment of patients with dementia and AD.” [4]

Human Trials Demonstrate Red Light Therapy's Potential as an Alzheimer's/Dementia Treatment

More Alzheimer’s Trials with Red Light Therapy are in Progress

The results of these initial human trials are immensely encouraging for AD & dementia patients and families looking for better treatment options, especially natural and non-invasive ones with no drugs, chemicals, or side effects.

As of early 2019, 3 more human trials on red light therapy and Alzheimer’s and dementia are in progress at the University of California and a hospital system in France. With these extremely positive early clinical results in people, more and larger studies and trials are being organized. The hope is that in the coming years, the base of evidence will be large enough to recommend light therapy as a vital treatment strategy to ward off the symptoms of Alzheimer’s and dementia — giving people and their families more quality time together.

The human results from recent years build on a larger base of similarly positive laboratory studies of rodent brains in Alzheimer’s and dementia models, which are outlined below.

Numerous trials are also underway that examine red light therapy’s positive effect on mental health. You can learn more about red light therapy and depression here.

Lab Dementia Models Show Both Red and Near Infrared Light Reduce Oxidative Stress and Aid Memory

A 2018 laboratory study assessed mice in an age-related dementia model and found that red light therapy treatments significantly reduced oxidative stress levels and restored memory function. The researchers also praised light therapy for being noninvasive, and having a high rate of tissue penetration and low phototoxicity.

They found red light “not only prevented early-stage memory decline but also rescued late-stage memory deficits.”

The study concluded that red light therapy’s success in lab studies “opens a promising opportunity to translate LED-therapy into clinical treatments for patients with dementia.” [2]

Researchers in a similar 2015 study with a mouse dementia model used near infrared (NIR) light instead of red, like the previous study. The NIR treatments were also effective and at reducing oxidative stress in the cerebellar cortex. The team concluded that NIR light treatments likely had the ability to mitigate degeneration in every region of the mouse brain. [5]

Light Therapy Prevents Brain Degeneration in Alzheimer’s Models

Several recent laboratory studies have published strong positive evidence for light therapy as a means to suppress the buildup of Beta-amyloid (Aβ), a protein that forms senile plaques in the brains of people with Alzheimer’s and dementia. Synaptic dysfunction, due to the disruptive binding of (Aβ) in the brain, is one of the first symptoms of AD many patients experience, and is responsible for driving initial cognitive decline. In the medical community, there’s a strong consensus that preventing this early synaptic dysfunction would be an effective therapeutic strategy for AD. For patients and families, that means keeping AD at bay so people can continue to live relatively normal lives for longer periods of time. [6]

To learn more about red light therapy’s positive impact on brain health and cognitive function, check out this article.

Red Light Therapy Improves Memory, Motor Skills, and Recognition in Alzheimer’s Models

Two separate 2017 laboratory studies assessed the hippocampus of rat brains in an Alzheimer’s model with light therapy treatments. Both studies demonstrated significantly reduced Aβ plaques in the light therapy-treated rats. Both studies also tested the subjects and found that treatments limited hippocampal neurodegeneration, with significantly improved spatial memory, recognition, and basic motor skills in the light therapy groups. [7,8]

Another recent laboratory result also demonstrated significant Aβ reduction and noted that NIR light can “effectively reduce synaptic vulnerability to damaging Aβ oligomers, thus furthering NIR light therapy as a viable treatment for AD.” [6]

Other Health Benefits of Red Light Therapy

Emerging clinical research is also showing the potential for other red light therapy benefits, like improved fitness and training, and better sleep and circadian rhythm. The initial research is also encouraging for skin health as well as for red light therapy and hormone health.

Conclusion: Red Light Therapy Shows Major Promise as an Alzheimer’s and Dementia Treatment

The initial clinical studies on red light therapy and Alzheimer’s & dementia treatment have been encouraging. Light therapy treatments are showing the potential to help delay the onset of Alzheimer’s symptoms, and hopefully even reverse or prevent brain degeneration and cognitive decline. 

To learn more about the wide-ranging benefits of red light therapy, check out our learn library, where we have collected articles about the science and benefits of red light therapy.

Scientific Sources and Medical References:

[1] Alzheimer’s Association, Facts & Figures.

[2] Zhang J, Yue X, et al. Antioxidant Redox Signaling. 2018 Jul 23. Illumination with 630 nm Red Light Reduces Oxidative Stress and Restores Memory by Photo-Activating Catalase and Formaldehyde Dehydrogenase in SAMP8 Mice.

[3] Berman MH, Halper JP, Nichols TW, et al. Photobiomodulation with Near Infrared Light Helmet in a Pilot, Placebo Controlled Clinical Trial in Dementia Patients Testing Memory and Cognition. J Neurol Neurosci. 2017;8(1).

[4] Saltmarche AE, et al. Significant Improvement in Cognition in Mild to Moderately Severe Dementia Cases Treated with Transcranial Plus Intranasal Photobiomodulation: Case Series Report. Photomed Laser Surg. 2017 Aug;35(8):432-441.

[5] Purushothuman S, Johnstone DM, Nandasena C., et al. Near infrared light mitigates cerebellar pathology in transgenic mouse models of dementia. Neurosci Lett. 2015 Mar 30;591:155-9.

[6] Comerota MM, Krishnan B, Taglialatela G. Near infrared light decreases synaptic vulnerability to amyloid beta oligomers. Scientific Reports. 2017 Nov 8;7(1):15012.

[7] da Luz Eltchechem C, Salgado ASI, et al. Transcranial LED therapy on amyloid-β toxin 25-35 in the hippocampal region of rats. Lasers in Med Science. 2017 May;32(4):749-756.

[8] Lu Y, Wang R, et al. Low-level laser therapy for beta amyloid toxicity in rat hippocampus. 2017 Jan;49:165-182.

Joovv light therapy products are indicated for use in the relief of muscle and joint pain, including arthritis and muscle spasm pain, and increasing of blood circulation, and relaxation of muscles. The information provided in this article is for educational purposes only and is not intended to support the safety or effectiveness of Joovv devices, or diagnose, treat, cure, or prevent any disease. It's not a substitute for a face-to-face consultation with your healthcare provider, and should not be construed as medical advice.

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